Bisphenol A (BPA)—an endocrine disruptor xenoestrogen—is widely spread in the environment. Lycopene (LYC) is an antioxidant. Background: The exact role of lycopene has not been studied in the past for its hepatoprotective effects. Hence it was decided to explore its anti-oxidant and. In this experimental approach we have established measurements of the hepatoprotective efficiency of lycopene using oxidative stress markers in both.

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Table 3 Effect of lycopene on low density lipoprotein-cholesterol, high density lipoprotein-cholesterol and free fatty acid levels in liver tissue. The usage of LYC, as antioxidant, produced pronounced hepatic protection that markedly ameliorated the severity of hepatic lesions and subsequently the hepatic functions.

High-density hepstoprotective cholesterol HDL-c and low-density lipoprotein cholesterol LDL-c were determined as described by Bachorik [ 29 ].

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BPA is a monomer found in plastic goods and affects adversely many organs especially the liver through induction of oxidation state. July 29, Article in press: Dietary carotenoids protect human cells from damage.

Chicago, IL, United States. The centrilobular hepatic necrosis, ballooning degeneration, fatty change and infiltrating lymphocytes were observed in NAFLD model group. Subscribe to Table of Contents Alerts. An interest has been aroused in utilizing natural products isolated from plants against chemical compounds generating tissue damage [ 16 ].

Hepatoprotective Effect of Olive and Argan Oils Supplemented with Tomato Lycopene in Wistar Rats

View at Google Scholar G. Finally, LYC credited to have a noticeable protective effect versus BPA provoked oxidative injury and apoptosis of the liver tissue. Lycopene LYC is an antioxidant phytochemical carotenoid. Gong ZM L- Editor: Effects of lycopene on body weight A and liver coefficient B.


Effect of lycopene on low density lipoprotein-cholesterol, high density lipoprotein-cholesterol and free fatty acid levels in liver tissue. All slides were lightly counterstained with hematoxylin for 30 seconds prior to dehydration and mounting [ 34 ]. These results could be attributed to the toxic effect of BPA that could encounter several lycopeje homeostatic pathways, among which neuronal appetite loop in the brain [ 38 ], where BPA lycoopene easily cross blood brain barrier and have estrogenic effect [ 39 ].

Finally, the 4th group was administrated both BPA heepatoprotective LYC at the same doses of the 2nd and 3rd groups daily via gavage. Oxidative Medicine and Cellular Longevity. Lycopnee are present naturally in the living cells as superoxide dismutase, catalase, glutathione reductase, and glutathione oxidase [ 13 ] or are available in food such as carotenoids, polyphenols, and vitamins C and E [ 14 ].

Stahl W, Sies H. BPA is metabolized primarily in the liver [ 7 ]. Spectrum of clinical lesions. In our data, BPA expressed lycipene effect on the liver evidenced by significant increase in the serum liver enzyme activities along with reduction in TP and albumin. Table 2 Effect of lycopene on liver antioxidant enzyme-specific activities, antioxidant and lipid peroxidation levels.

This can obviously illustrate the higher B. A Grade B Very good: Lycopene, the most important carotenoids, is a red lipophilic pigment containing 11 conjugated double bonds make lycopene a powerful radical scavenger.


View at Google Scholar J.

Liver, from each rat, was immediately enucleated, washed out with buffer saline, blotted by filter paper, and then weighed. Protective effect of lycopene on serum cholesterol and blood pressure: These results were in agreement with Kurcer et al. Protective effect of Zhuyeqing liquor, a Chinese traditional health liquor, on acute alcohol-induced liver injury in mice.

Hdpatoprotective and outcome of acute liver failure in the USA: The present results demonstrated that BPA had no effect on body and liver weights. Twenty-eight female Wistar rats were allocated equally into four groups: The potential role of lycopene for human health.

The reduction in serum SOD activity could be due to excessive consumption in the autoxidation procedure induced by BPA in the liver. The variation in yepatoprotective may be attributed to the diversity in diet composition, BPA exposure period, route and doses, and animal strain. The procedures for comet assay were followed as described by Abdelrazek et al. Mol Nutr Food Res.

MDA, an end-product of the breakdown of polyunsaturated fatty acids heppatoprotective related esters, is an important index of lipid peroxidation in many organ homogenates[ 17 ].

The results of the present study prove that lycopene exerts hepatoprotective effect against paracetamol and anti-tubercular drugs induced hepatic damage in rats. The body weight gain B.

China Peer-review report classification Grade A Excellent:

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